Mutations that extend lifespan in invertebrates typically render the animals resistant to multiple forms of lethal injury, whether the threat comes from oxidative agents, heat, heavy metals, or irradiation. Indeed, this stress resistance seems likely to represent the mechanism by which these mutations delay the aging process. Thus presumably much of the cellular and extracellular pathology that produces dysfunction and increases mortality risk in older animals is held in abeyance by the same, poorly defined, defenses that permit nematodes and flies to survive when exposed to external stress in an experimental setting. (more…)
Cellular Response to Oxidative Stress and Sensitivity of Transcription Factors to ROS That Determine the Response. It is establishe ...
The basic mechanisms of life and inheritance function much the same in worms, fruit flies, mice, and humans. That is one reason wh ...
The Late Biological Effects of Ionizing Radiation Exposure to ionizing radiation results in an increase in oxidative damage to DNA, ...
An increase in the concentration of free radicals, measured using electron spin resonance (ESR) spectroscopy, can reflect the degre ...
Many studies have shown that antibiotic drugs are often prescribed unnecessary or inappropriate. Drugs for elderly (geriatric d ...
First and foremost, many of the services supported by the Aging Network would not exist without network funding and advocacy. Without network services, an essential tier of the continuum of long-term care would be lost—the one that bridges total independence in one’s own home and institutionalization. (more…)
In some states, the Aging Network and the services it supports remain invisible or are low priority in the eyes of legislators an ...
New Zealand also initiated an Older Peoples Health Strategy with the following eight objectives: • Older people, their families ...
While assisted living is similar to home care, congregate housing, board and care homes, and nursing homes, it differs from those p ...
Several efforts, both public and private, are helping assisted living become more affordable by lowering the cost of constructing a ...
It is in this same period that college-and university-based Institutes for Learning in Retirement (ILRs, later renamed Lifelong ...
There is strong consensus among geriatricians and gerontologists that frailty is a clinical state of increased vulnerability and decreased ability to maintain homeostasis that is age-related problems and centrally characterized by declines in functional reserves across multiple physiologic systems. This vulnerability is age-related and also related to, but distinct from, disability and elderly disease states. (more…)
There are several dominant theories as to the underlying causes of physiologic vulnerability and compromised homeostasis of frail ...
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocr ...
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocr ...
Involuntary weight loss is the result of many chronic progressive diseases, often leading to diminished lean body mass, frailty, su ...
Pharmacodynamics describes the course of action of a drugs and aging at the effector organ level, in terms of duration and magnitud ...
Growing older results in the various changes in the anatomy and physiology of human cardiovascular system. This affects in both healthy patients and patients with hypertension. The heart gets a less powerful pump, and needs to bring more to do the same job. (more…)
First the blood vessels. The walls of the arteries stiffen with age. And the largest blood vessel in the body, the aorta, gets long ...
In older patients without apparent cardiovascular disease, the number of cardiac myocytes declines, while residual myocytes enlarge ...
Carotid sinus hypersensitivity ( more than 3-second pause or a decrease in systolic blood pressure = 50 mm Hg during carotid sinus ...
With heart disease risk being the number one cause of death among older Americans, you should pay particular attention to known ...
Neurocardiogenic Vasovagal syncope is more common in younger patients but also should be considered in elderly patients with unexpl ...
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocrine function. Several mechanisms interact in most systems to bring about the observed changes. Aging is associated with anatomic changes of the endocrine glands. In addition, with age, changes in hormone replacement secretion occur, including alterations in circadian or seasonal biorhythms, changes in pulsatile frequency or amplitude of growth hormone secretion, as well as absolute changes in mean serum hormonal levels. The three main hormone systems that show decline with age are the gonadal hormones (menopause and andropause), the adrenal steroids DHEA and DHEA-S (adrenopause), and the GH/IGF-1 axis (somatopause). (more…)
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocr ...
The accurate diagnosis of endocrine dysfunction in the elderly requires a high index of suspicion. Signs and symptoms of hormone de ...
The systemic benefits of exogenous Growth Hormone therapy in the healthy elderly remain unclear and controversial. Studies have ...
The prevalence of sexual dysfunction in women approaches 43%, and age is an important correlate. The underlying etiology of sexual ...
When approaching menopause or during post-menopause period, most women suffered from menopausal symptoms irritability like ...
Because it expresses my own orientation, I carry in my wallet a membership card to the Society for the Right to Die, which has imprinted on the back a signed statement of my living will.
When the aging process accelerates inexorably, you usually don’t just fail to wake up one morning because of old age. One of the many illnesses that afflict the elderly with increasing frequency will likely be the cause of death and dying. Here is where I feel a living will is important. (more…)
Elderly adults are becoming increasingly interested in learning about end-of-life issues. As a woman in her late 80s observed, ...
Married heterosexual couples automatically have a right to visit their loved ones in the hospital and to supervise their spouse’s f ...
Changes in the Family Every human being has the need for affection and to have someone toward whom he can express love and affec ...
Hospice is a philosophy of caring for dying patients and their families while emphasizing quality of life. Care is provided by ...
The majority associated with leading cause of deaths in America are due to medical health issues, not accidents, regardless of what ...
First the blood vessels. The walls of the arteries stiffen with age. And the largest blood vessel in the body, the aorta, gets longer and dilates as you get older. These developments can occur just from aging and in the absence of significant atherosclerosis in the vessels. They are secondary to changes that are happening to collagen and elastin and to deposits of calcium. The actual tonus (or tension) of the arteries also increases with the progressive thickening of the layer of the arterial wall that is present under the inside lining. These changes may contribute to high blood pressure and damage to the arteries, which encourage atherosclerosis. (more…)
Growing older results in the various changes in the anatomy and physiology of human cardiovascular system. This affects in both hea ...
In older patients without apparent cardiovascular disease, the number of cardiac myocytes declines, while residual myocytes enlarge ...
Aging is recognized as one variable factor of increase the risk of high blood pressure. Generally, as people get older, the blo ...
With heart disease risk being the number one cause of death among older Americans, you should pay particular attention to known ...