The Late Biological Effects of Ionizing Radiation Exposure to ionizing radiation results in an increase in oxidative damage to DNA, protein, and lipids in a dose-dependent manner. This increase is mainly the result of the increased rate of production of reactive oxygen species (ROS) and their direct attack on biomolecules. Late biological effects of ionizing radiation include accelerated aging disease on different levels. For example, an increase in the rate of the age-dependent accumulation of DNA damage in brain cells and of cross-links in collagen molecules has been observed in rodent tissues many months after they were exposed to ionizing radiation. (more…)
There are endogenous and external sources of ‘natural’ oxygen free radicals and other ROS. Thus, under normal conditions endogenous ...
An increase in the concentration of free radicals, measured using electron spin resonance (ESR) spectroscopy, can reflect the degre ...
Enzymatic Antioxidants Certain enzymes and many small water-soluble and lipid-soluble molecules can intercept and destroy free ra ...
Collagen elastin skin remedies are extremely important in keeping skin firm, and healthy. These two vital proteins play an impo ...
If you followed the anti-aging therapy methods, you may have heard of collagen supplements. These products are available on the mar ...
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocrine function. Several mechanisms interact in most systems to bring about the observed changes. Aging is associated with anatomic changes of the endocrine glands. In addition, with age, changes in hormone secretion occur, including alterations in circadian or seasonal biorhythms, changes in pulsatile frequency or amplitude of hormone secretion, as well as absolute changes in mean serum hormonal levels. (more…)
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocr ...
The accurate diagnosis of endocrine dysfunction in the elderly requires a high index of suspicion. Signs and symptoms of hormone de ...
The prevalence of sexual dysfunction in women approaches 43%, and age is an important correlate. The underlying etiology of sexual ...
The systemic benefits of exogenous Growth Hormone therapy in the healthy elderly remain unclear and controversial. Studies have ...
Involuntary weight loss is the result of many chronic progressive diseases, often leading to diminished lean body mass, frailty, su ...
Approximately 35% of the factors that influence life expectancy are inherited. Accelerated aging is therefore usually associated with genetic abnormalities. None of the accelerated aging syndromes, however, leads to a uniform, systematic “speeding up” of the aging process. A number of genetic disorders can lead to premature or accelerated aging (also referred to as progerias), including Down syndrome, Hutchinson– Gilford syndrome, and Werner’s syndrome. (more…)
Hutchinson-Gilford Progeria syndrome (HGPS) is also known as progeria or progeria of childhood. Unlike Werner Syndrome, which h ...
Cockayne syndrome is caused by the inheritance of genes that are thought to be of special importance in the repair of DNA withi ...
Ataxia-telangiectasia is yet another example of a hutchinson gilford progeria syndrome caused by a deficiency of a gene product ...
Dyskeratosis congenita is of special interest to gerontologists because it is caused by a mutation in the gene coding for the ...
Several gene mutations have been shown to cause Parkinson’s Disease, but they account for a small minority of patients and have n ...