Growing older results in the various changes in the anatomy and physiology of human cardiovascular system. This affects in both healthy patients and patients with hypertension. The heart gets a less powerful pump, and needs to bring more to do the same job. (more…)

The accumulative waste theory of aging, also known as the waste accumulation or garbage accumulation theory of aging, proposes that molecules damaged by oxidation and their by products (e.g., aged collagen, damaged enzymes), and damaged mitochondria (organelles responsible for cellular energy production) accumulate in postmitotic (non dividing cells) causing dysfunction, toxicity, aging, and cell death (see Error Catastrophe Theory of Aging).

There are several mechanisms by which garbage accumulation affects cells. (more…)