Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocrine function. Several mechanisms interact in most systems to bring about the observed changes. Aging is associated with anatomic changes of the endocrine glands. In addition, with age, changes in hormone replacement secretion occur, including alterations in circadian or seasonal biorhythms, changes in pulsatile frequency or amplitude of growth hormone secretion, as well as absolute changes in mean serum hormonal levels. The three main hormone systems that show decline with age are the gonadal hormones (menopause and andropause), the adrenal steroids DHEA and DHEA-S (adrenopause), and the GH/IGF-1 axis (somatopause). (more…)
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocr ...
The accurate diagnosis of endocrine dysfunction in the elderly requires a high index of suspicion. Signs and symptoms of hormone de ...
The systemic benefits of exogenous Growth Hormone therapy in the healthy elderly remain unclear and controversial. Studies have ...
The prevalence of sexual dysfunction in women approaches 43%, and age is an important correlate. The underlying etiology of sexual ...
When approaching menopause or during post-menopause period, most women suffered from menopausal symptoms irritability like ...
Pharmacodynamics describes the course of action of a drugs and aging at the effector organ level, in terms of duration and magnitude of action, and amplitude of and time to reach the peak action, for both therapeutic and adverse actions. Alterations in the number and affinity of drug receptors, postreceptor signaling processes, biochemical responses, homeostatic mechanisms, and body composition, in addition to higher likelihood of polypharmacy and concurrent pathological processes in older age, make elders more susceptible to adverse drug reactions, drug–drug interactions, or decreased/ increased sensitivity to some drug action. (more…)
There are several important changes in pharmacokinetics metabolism associated with aging that predispose the elderly to increas ...
Complications of Adverse Drug Reactions may include hospitalization, increased hospital stays and health care expenditures, morbidi ...
Something you and your doctor should appreciate is that getting older influences the way you react to drugs. Elderly patients are t ...
Addiction is more than frequent drug use. Recent scientific research provides strong evidence that drugs not only interfere w ...
Aside from the fibromyalgia antidepressants, very few drug classes have evidence for efficacy in the treatment of fibromyalgia fati ...