Mutations that extend lifespan in invertebrates typically render the animals resistant to multiple forms of lethal injury, whether the threat comes from oxidative agents, heat, heavy metals, or irradiation. Indeed, this stress resistance seems likely to represent the mechanism by which these mutations delay the aging process. Thus presumably much of the cellular and extracellular pathology that produces dysfunction and increases mortality risk in older animals is held in abeyance by the same, poorly defined, defenses that permit nematodes and flies to survive when exposed to external stress in an experimental setting. (more…)
Cellular Response to Oxidative Stress and Sensitivity of Transcription Factors to ROS That Determine the Response. It is establishe ...
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Many studies have shown that antibiotic drugs are often prescribed unnecessary or inappropriate. Drugs for elderly (geriatric d ...
The systemic benefits of exogenous Growth Hormone therapy in the healthy elderly remain unclear and controversial. Studies have ...