Cardiac Resynchronization Therapy improves functional capacity and quality of life in patients with persistent class III and IV heart failure despite optimal medical therapy, and there is also evidence that Cardiac Resynchronization Therapy may reverse structural remodeling in selected patients. Although individual trials of Cardiac Resynchronization Therapy were underpowered to assess survival, a meta-analysis of outcomes from four randomized trials involving more than 800 patients found that Cardiac Resynchronization Therapy reduces mortality from heart failure. (more…)

Neurocardiogenic Vasovagal syncope is more common in younger patients but also should be considered in elderly patients with unexplained syncope. Although the triggering mechanisms are complex and may differ among young and elderly patients, the efferent responses generally can be categorized as cardioinhibitory (pauses of = 3 seconds or heart rate <40 beats per minute for more than 10 seconds), vasodepressor (systolic blood pressure falls by 50 mm Hg or more without symptoms or 30 to 50 mm Hg with symptoms of syncope or presyncope, and the heart rate does not decrease by more than 10%), (more…)

Pacemaker therapy is indicated in patients with symptomatic bradycardia (syncope, presyncope, dyspnea, and exercise intolerance) correlated to sinus node dysfunction (pauses, persistent bradycardia, or chronotropic incompetence). In elderly patients, sinus node dysfunction is often associated with atrial tachyarrhythmias, including AF. Because of the frequent association of sinus node dysfunction with AF, VVI and VVIR pacing were once considered the preferred pacing modes. Recent studies suggest that atrial-based pacing in patients with sinus node dysfunction is beneficial for preventing progression of AF. (more…)

Carotid sinus hypersensitivity ( more than 3-second pause or a decrease in systolic blood pressure = 50 mm Hg during carotid sinus massage) predominantly affects elderly patients, although the prevalence in the general population has not been precisely defined. In elderly patients with recurrent syncope, carotid sinus hypersensitivity has been reported in up to 35% of cases. Permanent pacing in patients with carotid sinus syndrome (carotid sinus hypersensitivity associated with syncope) is indicated. Observational and randomized studies have shown that recurrent symptoms are significantly reduced after permanent pacemaker implantation in patients with carotid sinus syndrome. (more…)

Aging is associated with progressive fibrosis of the sinoatrial node and AV conduction system, resulting in bradycardia, which may be further exacerbated by disease and medications, resulting in symptoms requiring permanent pacemaker implantation. More than 80% of pacemaker recipients in the United States are older than 65 years, and the median age is 75 years. As the population ages, it is anticipated that the number of older persons requiring permanent cardiac pacemakers, as well as the associated costs, will continue to rise. (more…)

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The same genetic and cell approaches used for treatment of bradyarrhythmia can potentially be modified for tachyarrhythmias treatment. Arrhythmogenesis typically results from increased automaticity, triggered activity, or reentry. Different genetic approaches can, therefore, be designed based on the individual mechanism. (more…)

There are intrinsic changes in the cardiac pacemaker cells and the cardiac conduction system associated with aging, which increase the propensity of the elderly population to develop chronotropic incompetence, conduction block, and bradycardia overall. Moreover, the already-at-risk elderly population is more likely to receive and is more sensitive to a variety of cardiovascular agents that may cause further bradycardia through suppression of the pacemaker activity or AV block. (more…)