Mutations that extend lifespan in invertebrates typically render the animals resistant to multiple forms of lethal injury, whether the threat comes from oxidative agents, heat, heavy metals, or irradiation. Indeed, this stress resistance seems likely to represent the mechanism by which these mutations delay the aging process. Thus presumably much of the cellular and extracellular pathology that produces dysfunction and increases mortality risk in older animals is held in abeyance by the same, poorly defined, defenses that permit nematodes and flies to survive when exposed to external stress in an experimental setting. (more…)

Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocrine function. Several mechanisms interact in most systems to bring about the observed changes. Aging is associated with anatomic changes of the endocrine glands. In addition, with age, changes in hormone replacement secretion occur, including alterations in circadian or seasonal biorhythms, changes in pulsatile frequency or amplitude of growth hormone secretion, as well as absolute changes in mean serum hormonal levels. The three main hormone systems that show decline with age are the gonadal hormones (menopause and andropause), the adrenal steroids DHEA and DHEA-S (adrenopause), and the GH/IGF-1 axis (somatopause). (more…)

A decline in glucose tolerance with age is a common finding that leads to an increased incidence of type 2 diabetes (T2DM) in the elderly. By age 60, 18.3% of persons have diabetes. Nearly 50% of individuals with T2DM are over the age of 65 years. (more…)

The senses of smell and taste are termed chemical senses because they detect chemical stimuli and encode chemosensory information into neural signals. A variety of diagnostic terms have been used to describe smell and taste disorders. Standard classification terms for olfactory disorders are anosmia (absence of smell), hyposmia (diminished sensitivity of smell), and dysosmia (distortion of normal smell). Phantosmia, a type of dysosmia, refers to perception odor in absence of an odor stimulus, and parosmia refers to distortion of odor perception when an odor is present. For taste, diagnostic terms include ageusia (absence of taste), hypogeusia (diminished sensitivity of taste), and dysgeusia (distortion of normal taste). (more…)

There are differences on what exactly contribute to quality of life on a personal level from person to person. Although many older people in good health condition have the increase of physical problems that affect them and their businesses. Although these disorders are more common with age, including Alzheimer, dementia, arthritis, hypertension, heart disease, stroke, depression, kidneys problem; lung disease, cancer and men’s prostate disease. (more…)

Osteoporosis is disease affecting the bones, making them fragile and prone to fracture. Osteoporosis is defined as a systemic skeletal disease characterized by low bone mass and microarchitectural deterioraton of bone mass tissue, with a consequent increase in bone fragility and susceptibility to fracture. Osteoporosis is a condition characterized by mass loss of the normal density of bone. (more…)

It is never too late to promote life span extension through sensible diet. A study shows that a strict low-calorie diet can promote life span of mice more than 40 percent. Many studies have shown that using this method on starting young mice on a diet with calorie restriction can help them live months longer than animals fed a standard diet. But the new study shows that even 19 months old mice can be comparable to 60 and 65 years of life in human. Those can be achieved by eating fewer calories. (more…)

Your potential average and maximum life spans will be substantially increased by the nutrient-rich food.

Let’s say that your hereditary potential the age you might expect to reach based upon the genes you’ve inherited from your parents is to live to be 80 years old. Let’s assume that you started and stuck to a rather high percentage of calorie limit, beginning at age 20. Over that remaining 60 years you might expect to age at half the expected rate, be “functionally” 50 when you were in fact chronologically 80. Your 60 years would thus stretch out to 120. (more…)

I’ve been noticing my body’s growing inclination to slow down, how it’s starting to get tougher to get off the couch, how it takes longer to heal, how I groan a little more when getting out of bed in the morning. I see a trend for the next 60 years.

And, I’ve been playing with it and experimenting with how to avoid all that. You too can avoid body aches and pains in elderly by following these 7 Easy Steps. (more…)

The amount of “complete” protein a person requires per day is about 0.015 ounces per pound of body weight. This comes to around 2 ounces per day, depending on the size of the person. This amount is required to replace the protein the body loses daily in the form of discarded cells, and proteins broken down or “turned over” through metabolism. Such replacement protein is not used for energy but goes back into the structure of the body.

However, at low calorie levels, the body may divert some of this replacement protein into energy use, and leave you relatively deficient in protein for structural use. (more…)