Adipose Tissue Fat as a Dynamic Organ

Adipose Tissue Fat
Adipose tissue fat is not simply a reservoir for excess nutrients, but rather an active and dynamic organ capable of expressing biologically active fat-derived peptides (FDPs). At times of acute injury, macrophages contribute to the release of these peptides and the term inflammatory markers is often applied, but in the basal state, adipose tissue is the predominant source of production. Some of these FDPs may have a role in the development of the obesity metabolic syndrome of aging and other obesity-related diseases. (more…)

Body Fat Distribution and Caloric Restriction Principles

Body Fat Distribution

Not all body fat is equally bad for your health. It is widely known that body fat distribution is extremely important. There is increasing evidence for the deleterious effects of Visceral Fat on aging. Waist-to-hip ratio (WHR) is an epidemiological tool that demonstrates a correlation between Visceral Fat and development of diabetes mellitus, stroke, coronary artery disease, and mortality. This ratio is easily determined by dividing the measurement of waist circumference by hip circumference. (more…)

Ventricular Arrhythmias and Sudden Cardiac Death in Elderly

In older patients without apparent cardiovascular disease, the number of cardiac myocytes declines, while residual myocytes enlarge. Concurrently, there is an increase in elastic and collagenous tissue in all parts of the interstitial matrix and conduction system with advancing age. (more…)

Stroke Prevention in Atrial Fibrillation

Atrial Fibrillation affects approximately 2.3 million people in the United States and is the most common rhythm disorder among U.S. patients hospitalized with a primary diagnosis of an cardiac arrhythmia. The median age of Atrial Fibrillation patients is 75 years; 84% are older than 65 years. Pooled data from studies of chronic Atrial Fibrillation in North America, Britain, and Iceland suggest a prevalence of 0.5% to 1% in the general population. (more…)

Obesity and the Metabolic Syndrome: Age-Related & BMI

obesity Metabolic Syndrome

Concomitant with the global increase in obesity is the increase in the metabolic syndrome. The metabolic syndrome, also known as the metabolic syndrome of aging, syndrome X, and the insulin resistance syndrome, is a constellation of abnormal metabolism including glucose intolerance (impaired glucose tolerance, impaired fasting glucose, and type 2 diabetes & diabetes in elderly), central (abdominal) obesity in genes, dyslipidemia, and hypertension. (more…)

Female Androgen Deficiency Syndrome (FADS)

The prevalence of sexual dysfunction in women approaches 43%, and age is an important correlate. The underlying etiology of sexual dysfunction in women is complex. Nevertheless, hormonal changes such as loss of estrogens and androgens contribute significantly to some of the sexual difficulties experienced by aging women. (more…)

Pain in Elderly: Definition and Dimension

pain in elderly
As people growing older or become elderly, several health risks and health complications and problem may happened because the natural degeneration of human systems and organ. When you are growing older and become member of elderly population, some complications associated with general body aches and pains may occur. (more…)

Effect of Aging on the Heart and Cardiovascular System

Growing older results in the various changes in the anatomy and physiology of human cardiovascular system. This affects in both healthy patients and patients with hypertension. The heart gets a less powerful pump, and needs to bring more to do the same job. (more…)

Age-Related Changes in Pharmacodynamics

Pharmacodynamics describes the course of action of a drugs and aging at the effector organ level, in terms of duration and magnitude of action, and amplitude of and time to reach the peak action, for both therapeutic and adverse actions. Alterations in the number and affinity of drug receptors, postreceptor signaling processes, biochemical responses, homeostatic mechanisms, and body composition, in addition to higher likelihood of polypharmacy and concurrent pathological processes in older age, make elders more susceptible to adverse drug reactions, drug–drug interactions, or decreased/ increased sensitivity to some drug action. (more…)

Chronic Disease and the Quality of Life in Older Adults

quality of life older adults
There are differences on what exactly contribute to quality of life on a personal level from person to person. Although many older people in good health condition have the increase of physical problems that affect them and their businesses. Although these disorders are more common with age, including Alzheimer, dementia, arthritis, hypertension, heart disease, stroke, depression, kidneys problem; lung disease, cancer and men’s prostate disease. (more…)

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