Some medications exist for weight loss. These medications are moderately effective, although they often have side effects that limit their widespread use. The history of diet medications has been plagued with adverse health outcomes, including valvular heart disease and heart arrhythmias. Many of these medications have focused on increasing the metabolic rate or suppressing appetite. Wieght loss with orlistat and sibultramine medications are gaining more popular among people looking to loss their weight trough medications (more…)

Adipose tissue fat is not simply a reservoir for excess nutrients, but rather an active and dynamic organ capable of expressing biologically active fat-derived peptides (FDPs). At times of acute injury, macrophages contribute to the release of these peptides and the term inflammatory markers is often applied, but in the basal state, adipose tissue is the predominant source of production. Some of these FDPs may have a role in the development of the obesity metabolic syndrome of aging and other obesity-related diseases. (more…)

Not all body fat is equally bad for your health. It is widely known that body fat distribution is extremely important. There is increasing evidence for the deleterious effects of Visceral Fat on aging. Waist-to-hip ratio (WHR) is an epidemiological tool that demonstrates a correlation between Visceral Fat and development of diabetes mellitus, stroke, coronary artery disease, and mortality. This ratio is easily determined by dividing the measurement of waist circumference by hip circumference. (more…)

Cardiac Resynchronization Therapy improves functional capacity and quality of life in patients with persistent class III and IV heart failure despite optimal medical therapy, and there is also evidence that Cardiac Resynchronization Therapy may reverse structural remodeling in selected patients. Although individual trials of Cardiac Resynchronization Therapy were underpowered to assess survival, a meta-analysis of outcomes from four randomized trials involving more than 800 patients found that Cardiac Resynchronization Therapy reduces mortality from heart failure. (more…)

Several clinical tools are available for identification of patients at risk of cardiac arrhythmias or its consequences that may benefit from interventions to reduce morbidity and risk of sudden death. These include noninvasive tests, such as a standard (more…)

Hayflick suggested that the aging process was by a biological clock, which includes all living cells, controlled. The study found that in 1961 human fibroblast cells (lung, skin, muscles, heart) have a limited lifespan. Nutrition appears to affect the rate of cell division are: cell consists of 50 departments in a supercharged year, while the cells fed up to three times longer than normal cells to divide. (more…)

Atrial Fibrillation affects approximately 2.3 million people in the United States and is the most common rhythm disorder among U.S. patients hospitalized with a primary diagnosis of an cardiac arrhythmia. The median age of Atrial Fibrillation patients is 75 years; 84% are older than 65 years. Pooled data from studies of chronic Atrial Fibrillation in North America, Britain, and Iceland suggest a prevalence of 0.5% to 1% in the general population. (more…)

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The same genetic and cell approaches used for treatment of bradyarrhythmia can potentially be modified for tachyarrhythmias treatment. Arrhythmogenesis typically results from increased automaticity, triggered activity, or reentry. Different genetic approaches can, therefore, be designed based on the individual mechanism. (more…)

The prevalence of sexual dysfunction in women approaches 43%, and age is an important correlate. The underlying etiology of sexual dysfunction in women is complex. Nevertheless, hormonal changes such as loss of estrogens and androgens contribute significantly to some of the sexual difficulties experienced by aging women. (more…)

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There are several important changes in pharmacokinetics metabolism associated with aging that predispose the elderly to increased risk of druginduced side effects including cardiac arrhythmia.

First, advanced age is accompanied by a decrease in overall body weight, total body water, lean body mass, and intravascular volume, resulting in a greater volume of distribution (V d ), which is defined by the drug dose divided by drug plasma concentration (V d = dose/concentration). The reduced distribution volume will, therefore, lead to a higher drug concentration after a given dose in the elderly compared to the younger population. (more…)