Swiss scientists have discovered that knocking out the nuclear receptor corepressor 1 (NCoR1) gene in the muscles of mice allow the animals to run farther, and faster. Knocking out the same gene in fat cells eliminated the problem of diabetes in the mice. And those are only two tissues, of the many types of tissues in a mouse’s body. I wonder if knocking out the NCoR1 gene in human muscles would create a super athlete? Knocking out a particular gene in muscle lets mice run twice as far as normal. Knocking out the same gene in fat cells allows the animals to put on weight without developing type-2 diabetes.
The first hint comes from the Mayo Clinic's Darren Baker. Baker has developed a way of delaying symptoms of old age in mice, and h ...
It is never too late to promote life span extension through sensible diet. A study shows that a strict low-calorie diet can pro ...
The systemic benefits of exogenous Growth Hormone therapy in the healthy elderly remain unclear and controversial. Studies have ...
A special breed of mice lived up to three times longer than normal after University of Pittsburgh researchers injected them with st ...
Hutchinson-Gilford Progeria syndrome (HGPS) is also known as progeria or progeria of childhood. Unlike Werner Syndrome, which h ...
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The proportion of elderly at any age without any chronic conditions is small, and disease can trigger a cascade of events resulting in functional deficits and disability. An increase in the number of activities with which an elder has difficulty increases linearly with comorbidity, that is, coexistent medical conditions that further complicate not only the genesis of a functional deficit but also its treatment. For example, rehabilitation for a stroke for an individual who also has painful, degenerative changes in the foot and a low tolerance for stressful activity secondary to angina with exertion would present a particular rehabilitation challenge. Yet, this example encapsulates geriatric rehabilitation specialist’s emphasis on care and function, not cure and disease. (more…)
The overarching goal of physical therapy rehabilitation is to return the individual to as close to the premorbid level of funct ...
There are numerous basic Activities of Daily Living instruments that seek to quantify basic physical functions and obtain a numeric ...
Beneficiaries of the Medicare program have three rehabilitation-related benefits established by federal statute: physical thera ...
Most older adults adapt successfully to the multiple developmental and social changes and late life depression that are common ...
There are a number of issues that must be considered in geriatric pain assessment. The major issues that merit attention are pr ...
The majority associated with leading cause of deaths in America are due to medical health issues, not accidents, regardless of what your mother told you. The National Center for Health Statistics compiles the listing of killers and leading causes of death in America. A number of on the list you can not manage but others you can. There are several things that you can do to minimize getting the risk of the leading causes of death. If you eat right, exercise, don’t smoke, keep your weight under control, and manage your stress, then you are having a big change to live longer and having prolonged life than average American. (more…)
Cancer occurrence rates in a period of time for a given population is expressed in various ways. The incidence rate is a direct mea ...
Because it expresses my own orientation, I carry in my wallet a membership card to the Society for the Right to Die, which has impr ...
Obesity in the elderly is a major health crisis facing our population that may predispose the elderly to the same adverse healt ...
Results from several recently completed trials have important implications for the primary prevention of Sudden Cardiac Death Preve ...
Aerobic exercise is one form of exercise with low to moderate intensity which is done for a longer or a moderate duration. With ...
Growing older results in the various changes in the anatomy and physiology of human cardiovascular system. This affects in both healthy patients and patients with hypertension. The heart gets a less powerful pump, and needs to bring more to do the same job. (more…)
First the blood vessels. The walls of the arteries stiffen with age. And the largest blood vessel in the body, the aorta, gets long ...
In older patients without apparent cardiovascular disease, the number of cardiac myocytes declines, while residual myocytes enlarge ...
Carotid sinus hypersensitivity ( more than 3-second pause or a decrease in systolic blood pressure = 50 mm Hg during carotid sinus ...
With heart disease risk being the number one cause of death among older Americans, you should pay particular attention to known ...
Neurocardiogenic Vasovagal syncope is more common in younger patients but also should be considered in elderly patients with unexpl ...
A decline in glucose tolerance with age is a common finding that leads to an increased incidence of type 2 diabetes (T2DM) in the elderly. By age 60, 18.3% of persons have diabetes. Nearly 50% of individuals with T2DM are over the age of 65 years. (more…)
Concomitant with the global increase in obesity is the increase in the metabolic syndrome. The metabolic syndrome, also known ...
Not all body fat is equally bad for your health. It is widely known that body fat distribution is extremely important. Ther ...
The Late Biological Effects of Ionizing Radiation Exposure to ionizing radiation results in an increase in oxidative damage to DNA, ...
Adipose tissue fat is not simply a reservoir for excess nutrients, but rather an active and dynamic organ capable of expressing ...
One approach to understanding the senescent growth arrest is to examine the factors that are required for the division of young ...
There are new strategies to address the 3 critical factors for body health: blood sugar, insulin and inflammation. These formula guarantees that we will not get obese and be lean for life. Inflammation and obesity has relation that can be describing when we eat foods, it immediately causes high of blood sugar to drop, but then again it creates higher levels of the hormone insulin, which causes inflammation. (more…)
Obesity results from an imbalance between caloric consumption and caloric expenditure over a prolonged period. Weight gain occurs w ...
Concomitant with the global increase in obesity is the increase in the metabolic syndrome. The metabolic syndrome, also known ...
Adipose tissue fat is not simply a reservoir for excess nutrients, but rather an active and dynamic organ capable of expressing ...
Not all body fat is equally bad for your health. It is widely known that body fat distribution is extremely important. Ther ...
The systemic benefits of exogenous Growth Hormone therapy in the healthy elderly remain unclear and controversial. Studies have ...
Some researches on relation between exercise and body human health results indicate that in addition to increasing muscle capacity, physical activity can help improve strength, balance, joint mobility, flexibility, agility, the speed with which one walks and physical coordination as a whole. In addition, physical activity has effects favorably on metabolism, blood pressure regulation, and prevention of an excessive increase in weight. (more…)
Osteoporosis is disease affecting the bones, making them fragile and prone to fracture. Osteoporosis is defined as a systemic s ...
As a normal ageing process, as you grow older, you will lose muscle fiber. The composition between fats and muscles in your bod ...
Aerobic exercise is one form of exercise with low to moderate intensity which is done for a longer or a moderate duration. With ...
It has been proven over the years that strength training exercises have been used by athletes and sports enthusiasts to improve ...
With heart disease risk being the number one cause of death among older Americans, you should pay particular attention to known ...
The accumulative waste theory of aging, also known as the waste accumulation or garbage accumulation theory of aging, proposes that molecules damaged by oxidation and their by products (e.g., aged collagen, damaged enzymes), and damaged mitochondria (organelles responsible for cellular energy production) accumulate in postmitotic (non dividing cells) causing dysfunction, toxicity, aging, and cell death (see Error Catastrophe Theory of Aging).
There are several mechanisms by which garbage accumulation affects cells. (more…)
Aging theories cover the physiological, genetic, biochemical properties of a typical organism, and the way these properties cha ...
A number of global changes occur in the human nervous system with age. These changes affect the Autonomic Nervous System as well as ...
Reactive radicals of nitrogen (nitric oxide and derivatives such as peroxynitrite) and of oxygen (superoxide anion, hydrogen peroxi ...
The largest single risk factor for developing cancer is age. The incidence of cancer increases exponentially with age, although ...
Aging theories cover the biochemical, genetic, and physiological properties of a typical organism, and the way these propertie ...