The accumulative waste theory of aging, also known as the waste accumulation or garbage accumulation theory of aging, proposes that molecules damaged by oxidation and their by products (e.g., aged collagen, damaged enzymes), and damaged mitochondria (organelles responsible for cellular energy production) accumulate in postmitotic (non dividing cells) causing dysfunction, toxicity, aging, and cell death (see Error Catastrophe Theory of Aging).

There are several mechanisms by which garbage accumulation affects cells. (more…)

Aging theories cover the biochemical, genetic, and physiological properties of a typical organism, and the way these properties change with time. Genetic theories deal with speculations regarding the identity of aging genes, accumulation of errors in the genetic machinery, programmed senescence, and telomeres. Biochemical theories are concerned with energy metabolism, generation of free (more…)

Aging theories cover the physiological, genetic, biochemical properties of a typical organism, and the way these properties change with time. Theories of genetic dealing with the identity of aging obesity genes, accumulation of errors in the genetic machinery, programmed senescence, and telomeres theory. Biochemical theories are concerned with generation of free radicals, the rate of living, energy metabolism, and the health of mitochondria. While Theory of Physiological deal most entirely with the endocrine system and the purpose of hormones in governing the rate of cellular aging. (more…)