What Causes Cellular Senescence?

Cellular Senescence
Although many possible explanations for the mechanism that underlies the Hayflick limit have been proposed, it is still not clear what triggers the irreversible growth arrest seen in cellular senescent. A loss of telomeres, DNA at the end of each chromosome, has been considered an attractive candidate for the senescent trigger. The hypothesis was that a small amount of the telomere at the end of the chromosome (which is linear) is lost at each cell division due to the directionality of DNA polymerase. DNA polymerase can completely replicate one strand of DNA but cannot begin at the very end of the opposite strand. (more…)

Hayflick Limit Theory: Telomerase Lengthens Life of Normal Human Cells

Hayflick suggested that the aging process was by a biological clock, which includes all living cells, controlled. The study found that in 1961 human fibroblast cells (lung, skin, muscles, heart) have a limited lifespan. Nutrition appears to affect the rate of cell division are: cell consists of 50 departments in a supercharged year, while the cells fed up to three times longer than normal cells to divide. (more…)

Averages Human Life Expectancy Rate – Can You Alter It?

averages human life expectancy
Aging is not only about old age. This is an ongoing process which will define the stages of biological, psychological and social conditions in human lives. Aging has limit for averages human life expectancy rate. For centuries, many have tried modern science to delay human life expectancy rate so much from this frightening condition of man. There are millions of websites on the internet providing information on aging and more than half a million consultations related searches information on how to alter averages human life expectancy rate. (more…)

What Should Be Considered as Normal Ageing Process?

normal ageing process
Aging in human is a combination of two ageing processes: development or maturation, and senescence aging or decline. Development or maturation is the positive aspect of aging; humans typically acquire greater wisdom, experience, and expertise in specific fields as they grow older. Senescence aging, on the other hand, (more…)

Aging Theory — Telomeres Theory

Although we have not identified the genes controlling human life span, there is a genetic element called a telomere that clearly regulates the replicative life span of human cells in culture. A telomere is a simple DNA sequence that is repeated many times, located at the tips of each chromosome. Telomeres are not genes, but they are needed for the proper duplication of the chromosomes in dividing cells. (more…)