Dyskeratosis congenita is of special interest to gerontologists because it is caused by a mutation in the gene coding for the RNA component of telomerase, an enzyme that is essential for maintenance of the ends of chromosomes. The absence of telomerase should have particularly significant consequences for stem cells, certain differentiated somatic cells, and the germline, as there are normally high levels of this enzyme activity in such cell types. In the absence of telomerase, repeat units at the ends of chromosomes are lost, leading to chromosomal abnormalities and exit from the cell cycle. The absence of the enzyme in most forms of replicating somatic cells is thought to be the major factor in replicative senescence. (more…)
Hutchinson-Gilford Progeria syndrome (HGPS) is also known as progeria or progeria of childhood. Unlike Werner Syndrome, which h ...
Ataxia-telangiectasia is yet another example of a hutchinson gilford progeria syndrome caused by a deficiency of a gene product ...
Cockayne syndrome is caused by the inheritance of genes that are thought to be of special importance in the repair of DNA withi ...
Although we have not identified the genes controlling human life span, there is a genetic element called a telomere that clearly re ...
Approximately 35% of the factors that influence life expectancy are inherited. Accelerated aging is therefore usually associated wi ...
The prevalence of sexual dysfunction in women approaches 43%, and age is an important correlate. The underlying etiology of sexual dysfunction in women is complex. Nevertheless, hormonal changes such as loss of estrogens and androgens contribute significantly to some of the sexual difficulties experienced by aging women. (more…)
When approaching menopause or during post-menopause period, most women suffered from menopausal symptoms irritability like ...
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocr ...
As you probably know, sex hormone in women is declining with age. Men also experiencing the same, even though the declining rat ...
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocr ...
The accurate diagnosis of endocrine dysfunction in the elderly requires a high index of suspicion. Signs and symptoms of hormone de ...
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocrine function. Several mechanisms interact in most systems to bring about the observed changes. Aging is associated with anatomic changes of the endocrine glands. In addition, with age, changes in hormone secretion occur, including alterations in circadian or seasonal biorhythms, changes in pulsatile frequency or amplitude of hormone secretion, as well as absolute changes in mean serum hormonal levels. (more…)
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocr ...
The accurate diagnosis of endocrine dysfunction in the elderly requires a high index of suspicion. Signs and symptoms of hormone de ...
The prevalence of sexual dysfunction in women approaches 43%, and age is an important correlate. The underlying etiology of sexual ...
The systemic benefits of exogenous Growth Hormone therapy in the healthy elderly remain unclear and controversial. Studies have ...
Involuntary weight loss is the result of many chronic progressive diseases, often leading to diminished lean body mass, frailty, su ...
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocrine function. Several mechanisms interact in most systems to bring about the observed changes. Aging is associated with anatomic changes of the endocrine glands. In addition, with age, changes in hormone replacement secretion occur, including alterations in circadian or seasonal biorhythms, changes in pulsatile frequency or amplitude of growth hormone secretion, as well as absolute changes in mean serum hormonal levels. The three main hormone systems that show decline with age are the gonadal hormones (menopause and andropause), the adrenal steroids DHEA and DHEA-S (adrenopause), and the GH/IGF-1 axis (somatopause). (more…)
Altered cellular metabolism and intracellular and intercellular signaling with advancing age result in widespread changes in endocr ...
The accurate diagnosis of endocrine dysfunction in the elderly requires a high index of suspicion. Signs and symptoms of hormone de ...
The systemic benefits of exogenous Growth Hormone therapy in the healthy elderly remain unclear and controversial. Studies have ...
The prevalence of sexual dysfunction in women approaches 43%, and age is an important correlate. The underlying etiology of sexual ...
When approaching menopause or during post-menopause period, most women suffered from menopausal symptoms irritability like ...
Some researches on relation between exercise and body human health results indicate that in addition to increasing muscle capacity, physical activity can help improve strength, balance, joint mobility, flexibility, agility, the speed with which one walks and physical coordination as a whole. In addition, physical activity has effects favorably on metabolism, blood pressure regulation, and prevention of an excessive increase in weight. (more…)
Osteoporosis is disease affecting the bones, making them fragile and prone to fracture. Osteoporosis is defined as a systemic s ...
As a normal ageing process, as you grow older, you will lose muscle fiber. The composition between fats and muscles in your bod ...
Aerobic exercise is one form of exercise with low to moderate intensity which is done for a longer or a moderate duration. With ...
It has been proven over the years that strength training exercises have been used by athletes and sports enthusiasts to improve ...
With heart disease risk being the number one cause of death among older Americans, you should pay particular attention to known ...
You can easily address the causes of skin aging and skin greasiness, with the right skincare products. This article looks at the things that contribute to excessive oiliness and the things that can reduce it. Let’s start with the contributing factors.
Many cleansers, lotions, shampoos and other cosmetics contain mineral oil or petrolatum. These cause a greasy feeling, because they are not absorbed. They can also cause blemishes and pimples, (more…)
For decades, anti aging moisturizers haven't been much different from those designed for fresh young skin people. The primary c ...
If we want less wrinkles, we need to start as early in life as possible. What do we need to do? There are a number of important ...
Let's face it, you would love to have that fresh young skin you had when you were younger? However unless you have been taking ...
Collagen stimulation is the secret to smoother, firmer, and younger looking skin. This is common knowledge, however it is surprisin ...
Ever wonder how to remove wrinkles and regain the complexion you once had? Although it's hard to eliminate wrinkle all together ...
The largest single risk factor for developing cancer is age. The incidence of cancer increases exponentially with age, although death from cancer (cancer mortality) may decline at very old age. The inevitable age-dependent rise in cancer incidence is a feature of multicellular organisms that contain a substantial fraction of mitotic cells. Organisms such as flies and worms are composed primarily of post-mitotic cells, and hence do not develop cancer. (more…)
The sequencing of the human genome was begun in 1990 and completed in 2003. The International Human Genome Sequencing Consortiu ...
The classical view of carcinogenesis was that it was a two-‘hit’ process – initiation (genetic) and promotion (epigenetic). How ...
In every population of cells there are three types of cell. The first group consists of cycling cells, which continuously proli ...
Although many possible explanations for the mechanism that underlies the Hayflick limit have been proposed, it is still not cle ...
Oncogenes are damaged versions of normal genes (‘proto-oncogenes’) that control cell growth and differentiation. It is importan ...