Adipose tissue fat is not simply a reservoir for excess nutrients, but rather an active and dynamic organ capable of expressing biologically active fat-derived peptides (FDPs). At times of acute injury, macrophages contribute to the release of these peptides and the term inflammatory markers is often applied, but in the basal state, adipose tissue is the predominant source of production. Some of these FDPs may have a role in the development of the obesity metabolic syndrome of aging and other obesity-related diseases. (more…)

Obesity results from an imbalance between caloric consumption and caloric expenditure over a prolonged period. Weight gain occurs when there is a greater consumption of calories than expenditure. The expenditure of calories is complex and results from likely combinations of metabolic, genetic, and individual factors. Genetics and environment may predispose to weight gain, but it is only the consumption of calories in excess of utilization that can cause weight gain. (more…)