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Hutchinson-Gilford Progeria syndrome (HGPS) is also known as progeria or progeria of childhood. Unlike Werner Syndrome, which has an autosomal recessive mode of inheritance, it is caused by a dominant mutation of a type known as a gain of function or a dominant negative. The affected gene is known as Lamin A/C. It codes for a protein that coats the inner lining of the nuclei of cells. There is evidence that defective forms of the protein result in two broad classes of abnormalities – a mechanical weakness of nuclei, with herniations of nuclear material, and defects in the regulation of gene expression. There is also evidence of accelerated replicative senescence of cultured somatic cells, but this is not as striking as in Werner Syndrome. (more…)

Not only that the low birth rate leads directly to the aging population, a purely arithmetic on the number of young people, and economic and political context of these developments will strengthen the relationship. The traditional family-based between generations is not possible if we put more people involved (mostly women, will not survive longer than men), most with fewer children. Many countries face this problem in the world, and raise taxes on households of working age to pay for new programs for the aging population. (more…)

With the exploding popularity of anti-aging products today, you have probably heard of anti-aging HGH releasers. In fact, they are very popular these days as they are purported to be the key to the fountain of youth. But are they really? Let’s find out. (more…)