Concomitant with the global increase in obesity is the increase in the metabolic syndrome. The metabolic syndrome, also known as the metabolic syndrome of aging, syndrome X, and the insulin resistance syndrome, is a constellation of abnormal metabolism including glucose intolerance (impaired glucose tolerance, impaired fasting glucose, and type 2 diabetes & diabetes in elderly), central (abdominal) obesity in genes, dyslipidemia, and hypertension. (more…)

Potential benefits of T treatment in older men must be weighed against risks of adverse effects. In young hypogonadal men, physiological T replacement is low risk. In older men, risk–benefit ratios may be less advantageous. Minor adverse effects of T treatment include fluid retention, erythrocytosis, and sleep apnea, problems that may be more common in old men. Of greater concern are possible increases in atherosclerosis and greater risk of prostate cancer. (more…)